This test is used to evaluate the function of the adrenal glands. DHEA-sulfate is a weak male hormone (androgen) produced by the adrenal gland in both men and women. The adrenal gland is one of the major sources of androgens in women (the other being the ovaries, which produce testosterone).

DHEA-sulfate is measured in women showing symptoms of male body characteristics (virilism) or excessive hair growth (hirsutism).   It is also done in children who are maturing too early (precocious puberty)..